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Javadov, Sabzali
One or more keywords matched the following properties of Javadov, Sabzali
PropertyValue
keywords heart; mitochondria; oxidative stress; ischemia-reperfusion; modeling; cell death
overview I have a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology, with a focus on the roles of mitochondria in ischemia-reperfusion (IR), heart failure, and aging. My studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats, alloxan-induced diabetes in rabbits), ex-vivo (global IR in Langendorff-perfused isolated rat and mouse heart), and in vitro (hypertrophy, hypoxia/reoxygenation in cultured cells) models. Different pharmacological agents and conditional approaches have been used in my studies to prevent mitochondria-mediated cell death in cardiac diseases. Since 1997, my research focuses on the role of mitochondrial permeability transition pore (PTP) opening and mitochondrial swelling during cardiac IR injury and post-myocardial infarction heart failure. I successfully administered several projects in Europe, Canada, and PR, collaborated with other researchers, and produced several peer-reviewed publications from each project. Currently, my research is supported by NIH and NSF grants.
One or more keywords matched the following items that are connected to Javadov, Sabzali
Item TypeName
Academic Article Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Academic Article Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.
Academic Article Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.
Academic Article Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis.
Academic Article Direct renin inhibition exerts an anti-hypertrophic effect associated with improved mitochondrial function in post-infarction heart failure in diabetic rats.
Academic Article The role of PPARa in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.
Academic Article Mitochondrial permeability transition and cell death: the role of cyclophilin d.
Academic Article Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance.
Academic Article The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes.
Academic Article The calcium-ROS-pH triangle and mitochondrial permeability transition: challenges to mimic cardiac ischemia-reperfusion.
Academic Article Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery.
Academic Article Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK.
Academic Article Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.
Academic Article Cardiac metabolic pathways affected in the mouse model of barth syndrome.
Academic Article Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?
Academic Article The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion.
Academic Article Single muscle fiber contractile properties in diabetic RAT muscle.
Academic Article Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion.
Academic Article The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome.
Academic Article Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells.
Academic Article Angiotensin II-preconditioning is associated with increased PKCe/PKCd ratio and prosurvival kinases in mitochondria.
Academic Article Simple kinetic model of mitochondrial swelling in cardiac cells.
Academic Article Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts.
Academic Article Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria.
Academic Article High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities.
Academic Article Association between ROS production, swelling and the respirasome integrity in cardiac mitochondria.
Academic Article Different approaches to modeling analysis of mitochondrial swelling.
Academic Article Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach.
Academic Article Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction.
Academic Article In silico simulation of reversible and irreversible swelling of mitochondria: The role of membrane rigidity.
Academic Article Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes.
Academic Article Mitochondria in Health and Diseases.
Academic Article Mitochondrial angiotensin receptors and cardioprotective pathways.
Academic Article The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury.
Academic Article The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells.
Academic Article OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling.
Academic Article Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells.
Academic Article The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.
Academic Article Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.
Academic Article Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart.
Academic Article NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat.
Academic Article Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy.
Academic Article NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling.
Academic Article Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species.
Academic Article NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.
Academic Article Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection.
Concept Disease Models, Animal
Concept Mitochondria, Heart
Concept Models, Biological
Concept Models, Cardiovascular
Concept Myocardial Reperfusion
Concept Reperfusion Injury
Concept Myocardial Reperfusion Injury
Concept Cell Death
Concept Myocardial Ischemia
Concept Oxidative Stress
Academic Article [Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion].
Academic Article [Quantitative relationship between ischemic heart disease and parameters of energy metabolism].
Academic Article [Effect of phosphocreatine and phosphocreatinine on membrane phospholipid metabolism in acute myocardial ischemia].
Academic Article Quantitative evaluation of relationship between cardiac energy metabolism and post-ischemic recovery of contractile function.
Academic Article [Energy-related disorders of myocardial contractility in calcium overload of the cardiomyocytes].
Academic Article [Effect of phosphocreatine on the lysophosphoglyceride levels in total ischemia of the rat myocardium].
Academic Article [Study of the spectrum of rabbit myocardium nuclear DNAases using models of ischemia and diabetes mellitus].
Academic Article [Nuclear endo-DNAse from rabbit myocardium in ischemia and diabetes mellitus].
Academic Article Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition.
Academic Article Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.
Academic Article [Relation between mitochondrial respiratory function and postischemic recovery of the isolated heart contractility].
Academic Article Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Grant Biophysical multiscale modeling of mitochondrial swelling
Academic Article Beta-Amyloid Instigates Dysfunction of Mitochondria in Cardiac Cells.
Academic Article Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles.
Academic Article Unraveling the mechanisms of cardiolipin function: The role of oxidative polymerization of unsaturated acyl chains.
Academic Article Amyloid ? induces cardiac dysfunction and neuro-signaling impairment in the heart of an Alzheimer's disease model.
Search Criteria
  • heart mitochondria
  • oxidative stress
  • ischemia
  • reperfusion
  • modeling
  • cell death
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